Oncology Pipeline
Loxo@Lilly aims to create medicines that make life better for all those affected by cancer around the world. Bringing together the focus and spirit of a biotech with the scale, resources, and heritage of Lilly, our team is focused on rapidly delivering impactful new medicines for people with cancer. Our approach centers on creating oncology medicines that unequivocally show early signs of clinical activity and will matter to patients.
RET Inhibitor
Selpercatinib

Mulligan LM1
Target
Molecule
Clinical Development
References
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- Lipson D, et al. Nat Med. 2012;18(3):382-384.
- Takeuchi K, et al. Nat Med. 2012;18(3):378-381.
- Drilon A, et al. Nat Rev Clin Oncol. 2018;15(3):151-167.
- Parimi V, et al. NPJ Precis Oncol. 2023;7(1):10.
- Yang SR, et al. Clin Cancer Res. 2021;27(5):1316-1328.
- Kohno T, et al. Carcinogenesis. 2020;41(2):123-129.
- Li AY, et al. Cancer Treat Rev. 2019;81:101911.
- Hofstra RM, et al. Nature. 1994;367(6461):375-376.
- Agrawal N, et al. J Clin Endocrinol Metab. 2013;98(2):E364-E369.
- Taccaliti A, et al. Curr Genomics. 2011;12(8):618-625.
- Subbiah V, et al. Ann Oncol. 2018;29:1869-1876.
- Drilon A, et al. LIBRETTO-001: A phase 1 study of LOXO-292, a potent and highly selective RET inhibitor, in patients with RET-altered cancers. Presented at: ASCO Annual Meeting; June 1-5, 2018; Chicago, IL.
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The safety and efficacy of the agents under investigation have not been established. There is no guarantee that the agents will receive regulatory approval and become commercially available for the uses being investigated.