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therapeutic target
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cancer type

Bruton's Tyrosine Kinase (BTK)

CLL/SLL or NHL
Pirtobrutinib
Enrolling
Enrolling
Enrolling
Enrolling
Enrolling

CDK4 & 6

Breast Cancer
Abemaciclib
Breast Cancer or NSCLC
Abemaciclib
Breast Cancer
Abemaciclib
Enrolling
Neuroblastoma or Pediatric Cancer
Abemaciclib
Prostate Cancer
Abemaciclib
Enrolling
Prostate Cancer
Abemaciclib
Enrolling
Prostate Cancer
Abemaciclib

FGFR3

Enrolling
Advanced Solid Tumors
LOXO-435

Kirsten Rat Sarcoma Viral Oncogene (KRAS) G12C

Enrolling
Colorectal Cancer, NSCLC, or Other Advanced Solid Tumors
LY3537982
Lung Cancer or NSCLC
LY3537982

Next-Generation Rearranged During Transfection (Next-Gen RET)

Enrolling
Lung Cancer, Medullary Thyroid Cancer, or Other Advanced Solid Tumors
LOXO-260

PI3Kα

Enrolling
Advanced Solid Tumors
LOXO-783

Rearranged During Transfection (RET)

Enrolling
NSCLC, Medullary Thyroid Cancer, Papillary Thyroid Carcinoma, or Other Advanced Solid Tumors
Selpercatinib
Enrolling
Pediatric Cancer
Selpercatinib
Enrolling
Medullary Thyroid Cancer
Selpercatinib

Selective Estrogen Receptor Degrader (SERD)

Breast Cancer or Endometrial Cancer
Imlunestrant
Enrolling
Enrolling

Vascular Endothelial Growth Factor Receptor-2 (VEGFR2)

The safety and efficacy of the agents under investigation have not been established. There is no guarantee that the agents will receive regulatory approval and become commercially available for the uses being investigated.