Oncology Pipeline

For more than 50 years, Lilly has been dedicated to delivering life-changing medicines and support to people living with cancer and those who care for them. Lilly is determined to build on this heritage and continue making life better for all those affected by cancer around the world. In 2019 Lilly created Loxo Oncology at Lilly, with the goal of rapidly delivering impactful new medicines for people with cancer. Our approach centers on creating new medicines that work in early clinical development and will matter to patients.

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therapeutic target
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by phase
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cancer type

Advanced Solid Tumors

Pediatric Cancer
Abemaciclib
Advanced Solid Tumors
LY3410738
Colorectal Cancer, NSCLC, or Other Advanced Solid Tumors
LY3537982
Lung Cancer, Medullary Thyroid Cancer, Other Advanced Solid Tumors, or Thyroid Cancer
LOXO-260
NSCLC, Medullary Thyroid Cancer, Papillary Thyroid Carcinoma, or Other Advanced Solid Tumors
RET Inhibitor Enrolling
Selpercatinib
Pediatric Cancer
RET Inhibitor Enrolling
Selpercatinib

Breast Cancer

Breast Cancer
Abemaciclib
Breast Cancer
Abemaciclib
Breast Cancer
Abemaciclib
Breast Cancer or Endometrial Cancer
Imlunestrant
Breast Cancer
Imlunestrant
Breast Cancer
Imlunestrant

Gastrointestinal Cancer

Colorectal Cancer, NSCLC, or Other Advanced Solid Tumors
LY3537982

Genitourinary Cancer

Prostate Cancer
Abemaciclib
Prostate Cancer
Abemaciclib
Prostate Cancer
Abemaciclib

Gynecologic Cancer

Breast Cancer or Endometrial Cancer
Imlunestrant

Hematologic Cancer

Advanced Hematologic Malignancies
BCL-2 Inhibitor Enrolling
LOXO-338
CLL/SLL
BTK Inhibitor Enrolling
Pirtobrutinib (LOXO-305)
CLL/SLL
BTK Inhibitor Enrolling
Pirtobrutinib (LOXO-305)
CLL/SLL
BTK Inhibitor Enrolling
Pirtobrutinib (LOXO-305)
CLL/SLL or NHL
BTK Inhibitor Enrolling
Pirtobrutinib (LOXO-305)
MCL
BTK Inhibitor Enrolling
Pirtobrutinib (LOXO-305)
Advanced Hematologic Malignancies
LY3410738

Lung Cancer

Colorectal Cancer, NSCLC, or Other Advanced Solid Tumors
LY3537982
Lung Cancer, Medullary Thyroid Cancer, Other Advanced Solid Tumors, or Thyroid Cancer
LOXO-260
NSCLC
RET Inhibitor Enrolling
Selpercatinib
NSCLC
RET Inhibitor Enrolling
Selpercatinib

Sarcoma

Pediatric Cancer
Ramucirumab

Thyroid Cancer

Lung Cancer, Medullary Thyroid Cancer, Other Advanced Solid Tumors, or Thyroid Cancer
LOXO-260
Medullary Thyroid Cancer
RET Inhibitor Enrolling
Selpercatinib

The safety and efficacy of the agents under investigation have not been established. There is no guarantee that the agents will receive regulatory approval and become commercially available for the uses being investigated.